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Summary of Changes in Estimated Fair Value (Detail)
$ in Thousands
3 Months Ended
Mar. 31, 2019
USD ($)
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]  
Balance as of December 31, 2018 $ 11,698
Net change in the fair value 5,352
Addition of derivative related to 2019 Secured Term Loan 2,372
Settlement of Lonza award (15,025)
Balance as of March 31, 2019 4,397
Embedded derivative liabilities  
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]  
Balance as of December 31, 2018 2,497
Net change in the fair value (472)
Addition of derivative related to 2019 Secured Term Loan 2,372
Balance as of March 31, 2019 4,397
Lonza award  
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]  
Balance as of December 31, 2018 9,201
Net change in the fair value 5,824
Settlement of Lonza award $ (15,025)