Summary of Significant Accounting Policies - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2019 USD ($) Customer	Mar. 31, 2018 Customer
Summary Of Significant Accounting Policies [Line Items]
Operating leases, right-of-use assets	$ 1,734,000
Operating leases, liabilities	2,683,000
Accounting Standards Update (“ASU”) No. 2016-02
Summary Of Significant Accounting Policies [Line Items]
Operating leases, right-of-use assets	2,100
Operating leases, liabilities	$ 3,300
Maximum
Summary Of Significant Accounting Policies [Line Items]
Leasing arrangements terms	1 year
Andexxa Specialty Distributor | Customer Concentration Risk | Sales Revenue, Net
Summary Of Significant Accounting Policies [Line Items]
Number of customers representing more than ten percent of revenue | Customer	4
Andexxa Specialty Distributor | Customer Concentration Risk | Sales Revenue, Net | Minimum
Summary Of Significant Accounting Policies [Line Items]
Concentration risk percentage	10.00%
Collaboration Revenue Customers | Customer Concentration Risk | Sales Revenue, Net
Summary Of Significant Accounting Policies [Line Items]
Number of customers representing more than ten percent of revenue | Customer		3
Number of customers representing less than ten percent of revenue | Customer	3
Collaboration Revenue Customers | Customer Concentration Risk | Sales Revenue, Net | Minimum
Summary Of Significant Accounting Policies [Line Items]
Concentration risk percentage		10.00%
Collaboration Revenue Customers | Customer Concentration Risk | Sales Revenue, Net | Maximum
Summary Of Significant Accounting Policies [Line Items]
Concentration risk percentage	10.00%