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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Income Statement [Abstract]    
Collaboration and license revenue $ 5,128 $ 8,258
Operating expenses:    
Research and development 30,645 58,813
Selling, general and administrative 15,021 14,751
Total operating expenses 45,666 73,564
Loss from operations (40,538) (65,306)
Interest and other income, net 413 332
Interest expense (1,639)  
Net loss (41,764) (64,974)
Net loss attributable to noncontrolling interest (SRX Cardio) 45  
Net loss attributable to Portola $ (41,719) $ (64,974)
Net loss per share attributable to Portola common stockholders:    
Basic and diluted $ (0.74) $ (1.15)
Shares used to compute net loss per share attributable to Portola common stockholders:    
Basic and diluted 56,692,788 56,397,881