Long-term Debt - Additional Information (Detail)	1 Months Ended		3 Months Ended
	Feb. 28, 2017 USD ($)	Dec. 31, 2016 USD ($) PromissoryNote	Mar. 31, 2017 USD ($)
Debt Instrument [Line Items]
Carrying value of notes payable		$ 49,815,000	$ 50,485,000
Long-term debt			47,803,000
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa
Debt Instrument [Line Items]
Embedded derivative liabilities			600,000
Amount received under royalty sales agreement	$ 50,000,000
Additional amount receivable upon U.S. regulatory approval	100,000,000
Royalty sales agreement fee			2,000,000
Additional debt issuance costs			600,000
Interest expense, including amortization of debt discount			900,000
Long-term debt			47,800,000
Payment-in-kind interest expense			900,000
Outstanding debt, net of unamortized debt discount			2,500,000
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Maximum
Debt Instrument [Line Items]
Repayment amount	$ 125,000,000
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Scenario One
Debt Instrument [Line Items]
Percentage of royalty obligated to pay of net worldwide sales	2.00%
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Scenario Two
Debt Instrument [Line Items]
Target payment for royalty obligation	$ 100,000,000
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Scenario Two | Maximum
Debt Instrument [Line Items]
Percentage of royalty obligated to pay of net worldwide sales	7.85%
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Scenario Two | Minimum
Debt Instrument [Line Items]
Percentage of royalty obligated to pay of net worldwide sales	3.58%
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Scenario Three
Debt Instrument [Line Items]
Percentage of royalty obligated to pay of net worldwide sales	195.00%
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa | Scenario Three | Minimum
Debt Instrument [Line Items]
Target payment for royalty obligation	$ 150,000,000
HealthCare Royalty Partners and its Affiliates (“HCR”) | Fair Value, Inputs, Level 3 | Andexanet Alfa
Debt Instrument [Line Items]
Estimated fair value of long-term debt			43,300,000
HealthCare Royalty Partners and its Affiliates (“HCR”) | Andexanet Alfa License Agreement with All Countries Excluding Japan
Debt Instrument [Line Items]
Notes payable, accrued interest			$ 900,000
Effective interest rate			13.80%
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer")
Debt Instrument [Line Items]
Debt instrument repayment terms, description			if the approval of andexanet alfa in the USA and EU is not achieved by January 1, 2019, we are able to reduce the repayment amount to $60.0 million if such amount is paid by December 31, 2021 and regardless of the timing of regulatory approval, we may reduce the repayment amount to $62.5 million if such amount is paid by December 31, 2023. Any unpaid amounts shall become immediately due upon: 1) our change of control; 2) event of default; and 3) termination for breach. We have the right to prepay the repayment amount at any time without any penalty.
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | Paid by December 31, 2021
Debt Instrument [Line Items]
Repayment amount		$ 60,000,000
Repayment date		Dec. 31, 2021
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | Paid by December 31, 2023
Debt Instrument [Line Items]
Repayment amount		$ 62,500,000
Repayment date		Dec. 31, 2023
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | Andexanet Alfa License Agreement with All Countries Excluding Japan
Debt Instrument [Line Items]
Percentage of license fees and milestone payments converted to notes payable upon initial regulatory approval not achieved		50.00%
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | United States and European Union
Debt Instrument [Line Items]
Initial regulatory approval date		Jan. 01, 2019
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | United States and European Union | Andexanet Alfa License Agreement with All Countries Excluding Japan
Debt Instrument [Line Items]
Percentage of net sales to be paid in each quarter		5.00%
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | Japan License Agreement
Debt Instrument [Line Items]
Percentage of payment receivable upon initial regulatory approval not achieved		100.00%
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | Promissory Notes
Debt Instrument [Line Items]
Proceeds from notes payable		$ 50,000,000
Number of debt instruments | PromissoryNote		2
Promissory notes, face amount		$ 65,000,000
Promissory notes due date		2024-12
Notes payable, accrued interest		$ 100,000	$ 700,000
Carrying value of notes payable		49,800,000	50,500,000
Embedded derivative liabilities		$ 300,000
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer") | Promissory Notes | Fair Value, Inputs, Level 3
Debt Instrument [Line Items]
Estimated fair value of notes payable			$ 54,700,000