Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 135,669	$ 188,480
Short-term investments	182,528	130,291
Restricted cash (SRX Cardio)	174	178
Prepaid research and development	5,898	7,299
Prepaid expenses and other current assets	3,312	2,680
Total current assets	327,581	328,928
Property and equipment, net	5,795	6,143
Intangible asset	3,151	3,151
Prepaid and other long-term assets	4,168	5,214
Total assets	340,695	343,436
Current liabilities:
Accounts payable	9,487	14,546
Accrued compensation and employee benefits	3,399	4,806
Accrued research and development	11,169	23,818
Accrued and other liabilities	3,283	1,696
Deferred revenue, current portion	20,798	20,798
Total current liabilities	48,136	65,664
Notes payable, long-term	50,485	49,815
Long term debt	47,803
Long term obligation to Collaborator	8,000	8,000
Deferred revenue, long-term	19,837	24,965
Other long-term liabilities	2,707	2,303
Total liabilities	176,968	150,747
Stockholders’ equity:
Preferred stock, $0.001 par value, 5,000,000 shares authorized; no shares issued and outstanding
Common stock, $0.001 par value, 100,000,000 shares authorized at March 31, 2017 and December 31, 2016; 57,009,237 and 56,544,218 shares issued and outstanding at March 31, 2017 and December 31, 2016, respectively	58	57
Additional paid-in capital	1,121,628	1,108,832
Accumulated deficit	(959,980)	(918,345)
Accumulated other comprehensive income/(loss)	(91)	(12)
Total stockholders’ equity	161,615	190,532
Noncontrolling interest (SRX Cardio)	2,112	2,157
Total stockholders' equity	163,727	192,689
Total liabilities and stockholders’ equity	$ 340,695	$ 343,436