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Stock-Based Compensation - Additional Information (Detail) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Jan. 31, 2016
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock reserved, shares 2,391,556      
Percentage increase in number of common stock outstanding 5.00%      
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan 12,205,425      
Term of stock options granted 10 years      
Vesting period 4 years      
Aggregate intrinsic value of stock options exercised $ 964,000 $ 35,900,000 $ 12,500,000  
Total estimated grant date fair value of stock options vested $ 20,800,000 $ 12,000,000 $ 9,000,000  
Weighted-average per share fair value of employee stock options granted $ 17.15 $ 22.84 $ 15.73  
Stock-based compensation expense $ 30,362,000 $ 22,858,000 $ 9,333,000  
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 41,800,000      
Unamortized share based compensation expected recognition period 2 years 7 months 6 days      
Remaining contractual life 6 years 10 months 24 days      
Aggregate intrinsic value of outstanding PSOs $ 22,295,000      
Employee stock purchase plan        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock reserved, shares 1,696,977      
Percentage increase in number of common stock outstanding 2.00%      
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan 1,818,314      
Exercise price of stock options granted as a minimum percentage of fair value of common stock 85.00%      
Dividend yield 0.00% 0.00% 0.00%  
Incentive Stock Options        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Exercise price of stock options granted as a minimum percentage of fair value of common stock 100.00%      
Nonstatutory Stock Options        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Exercise price of stock options granted as a minimum percentage of fair value of common stock 85.00%      
10% or more        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Exercise price of stock options granted as a minimum percentage of fair value of common stock 110.00%      
Percentage of voting stock 10.00%      
Employee Stock Option        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense $ 21,200,000 $ 15,800,000 $ 8,300,000  
Dividend yield 0.00% 0.00% 0.00%  
Performance Stock Options (PSOs)        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense $ 463,000      
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 2,120,000      
Unamortized share based compensation expected recognition period 1 year 8 months 12 days      
Remaining contractual life 9 years 3 months 18 days      
Aggregate intrinsic value of outstanding PSOs $ 0      
Share based compensation, options weighted average exercise price $ 23.76      
Dividend yield 0.00% 0.00% 0.00%  
Restricted Stock Units (RSUs)        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Vesting period 3 years      
Stock-based compensation expense $ 5,300,000 $ 1,500,000    
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 9,900,000      
Unamortized share based compensation expected recognition period 1 year 10 months 24 days      
Grant date of fair value $ 1,700,000      
Vested date of fair value $ 1,700,000      
Weighted-average grant date of fair value $ 28.01 $ 30.74    
Performance Stock Units (PSUs)        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense $ 2,500,000 $ 2,300,000    
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 704,000      
Unamortized share based compensation expected recognition period 2 years      
Grant date of fair value $ 658,000      
Vested date of fair value $ 397,000      
Weighted-average grant date of fair value $ 33.49 $ 29.35    
PSUs Vested during the year   0 0  
Dividend yield 0.00%      
Performance Stock Units (PSUs) | Maximum        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Performance-based RSUs awarded based on achievement of development goals, available for grant       102,906
Nonemployee Stock Options        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Vesting period 4 years      
Share based compensation, options granted 52,000 66,041 33,888  
Share based compensation, options weighted average exercise price $ 24.85 $ 40.85 $ 25.41  
Stock-based compensation $ 77,000 $ 2,790,000 $ 769,000