Consolidated Statements of Comprehensive Income (Loss) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Statement Of Income And Comprehensive Income [Abstract]
Net loss	$ (268,113)	$ (226,505)	$ (137,125)
Other comprehensive income:
Unrealized gain (loss) on available-for-sale securities, net of tax	138	89	(294)
Comprehensive loss	(267,975)	(226,416)	(137,419)
Comprehensive income attributable to noncontrolling interest (SRX Cardio)	(930)
Total comprehensive loss attributable to Portola	$ (268,905)	$ (226,416)	$ (137,419)