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Stock Based Compensation (Tables)

12 Months Ended

Dec. 31, 2016

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

The following table summarizes stock option activity, under our 2013 Plan and related information:

	Shares
	Subject to			Weighted-
	Outstanding			Average Exercise
	Stock Options			Price Per Share
Balance at December 31, 2015		4,731,483		$	24.19
Options granted		1,649,836			29.03
Options exercised		(54,045	)		7.42
Options canceled		(510,158	)		29.45
Balance at December 31, 2016		5,817,116		$	25.26

Additional Information Related to the Status of Stock Options

Additional information related to the status of stock options at December 31, 2016, is as follows (aggregate intrinsic value in thousands):

			Weighted-
			Average		Remaining
			Exercise Price		Contractual		Aggregate
	Shares		Per Share		Life		Intrinsic Value
Outstanding		5,817,116	$	25.26		6.9	$	22,295
Vested and expected to vest		5,680,016	$	25.11		6.9	$	22,267
Vested		3,310,206	$	20.29		5.7	$	21,966

Summary of PSO Activity

The following table summarizes PSO activity under our 2013 Plan and related information:

	Shares
	Subject to			Weighted-
	Outstanding			Average Exercise
	Stock Options			Price Per Share
Balance at December 31, 2015		–		$	–
Options granted		271,122			23.76
Options exercised		–			–
Options canceled		(90,370	)		23.76
Balance at December 31, 2016		180,752		$	23.76

Summary of RSU Activity

The following table summarizes RSU activity, under our 2013 Plan and related information:

	Shares
	Subject to			Weighted-
	Outstanding			Average grant date
	RSU's			fair value per share
Balance at December 31, 2015		167,750		$	30.86
RSUs granted		495,806			28.01
RSUs released		(55,195	)		30.88
RSUs canceled		(61,854	)		29.94
Balance at December 31, 2016		546,507		$	28.38

Summary of PSU Activity

The following table summarizes PSU activity, under our 2013 Plan and related information:

	Shares
	Subject to			Weighted-
	Outstanding			Average grant date
	PSU's			fair value per share
Balance at December 31, 2015		205,261		$	29.33
PSUs granted		102,906			33.49
PSU's released		(13,170	)		50.00
PSUs canceled		(9,131	)		49.36
Balance at December 31, 2016		285,866		$	29.24

Classification of Stock-Based Compensation Expense

Stock-based compensation expense, net of estimated forfeitures, is reflected in the consolidated statements of operations as follows (in thousands):

	Year Ended December 31,
	2016		2015		2014
Research and development	$	12,905	$	11,653	$	4,551
Selling, general and administrative		17,457		11,205		4,782
Total stock-based compensation	$	30,362	$	22,858	$	9,333

Summary of Weighted-Average Assumptions of Fair Value Awards

The following table illustrates the weighted-average assumptions for the Black-Scholes option-pricing model used in determining the fair value of these awards:

	Year Ended December 31,
	2016	2015		2014
Risk-free interest rate
Stock options	1.01%-2.10%	1.54%-1.93%		1.81%-1.89%
Performance stock options	1.34%-1.50%	–		–
ESPP	0.26%-0.50%		0.14%		0.08%
Expected term
Stock options	5.0 -6.1 years	6.0 years		6.0 years
Performance stock options	5.4 -6.4 years	–		–
ESPP	0.5 years	0.5 years		0.5 years
Expected volatility
Stock options	62% - 66%	64% - 66%		69% - 80%
Performance stock options	65%-66%	–		–
ESPP	54%-99%		62%		73%
Dividend yield
Stock options	–	–		–
Performance stock options	–	–		–
ESPP	–	–		–