Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016		Sep. 30, 2015
Operating activities
Net loss	$ (213,349)		$ (160,399)
Adjustments to reconcile net loss to cash used in operating activities:
Depreciation and amortization	1,423		942
Amortization of premium on investment securities	962		2,548
Stock-based compensation expense	22,464		16,032
Gain on retirement of equipment			(11)
Changes in operating assets and liabilities:
Receivables from collaborators	(4,000)		57
Prepaid research and development	1,401		(17,753)
Prepaid expenses and other current assets	(1,537)		3,000
Prepaid and other long-term assets	5,677		2,625
Accounts payable	(1,286)		(5,332)
Accrued compensation and employee benefits	(1,942)		383
Accrued research and development	(8,762)		11,197
Accrued and other liabilities	(249)		2,276
Deferred revenue	16,689		(7,154)
Other long-term liabilities	(565)		1,522
Net cash used in operating activities	(183,074)		(150,067)
Investing activities
Purchases of property and equipment	(1,564)		(3,150)
Increase in restricted cash (SRX Cardio)	(1,589)
Proceeds from sales of equipment			11
Purchases of investments	(197,650)		(187,166)
Proceeds from maturities of investments	294,619		241,422
Net cash provided by investing activities	93,816		51,117
Financing activities
Proceeds from public offering of common stock, net of underwriters discount			108,772
Payment of public offering cost	(242)		(358)
Proceeds from issuance of common stock pursuant to equity award plans	1,673		10,744
Net cash provided by financing activities	1,431		119,158
Net (decrease) increase in cash and cash equivalents	(87,827)		20,208
Cash and cash equivalents at beginning of period	186,488	[1]	57,514
Cash and cash equivalents at end of period	$ 98,661	[1]	$ 77,722

[1] Amounts include the assets and liabilities of SRX Cardio, LLC, a consolidated variable interest entity (“VIE”). Portola's interests and obligations with respect to the VIE's assets and liabilities are limited to those accorded to Portola in its agreement with the VIE. See Note 7, “Asset Acquisition and License Agreements,” to these condensed consolidated financial statements.