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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Income Statement [Abstract]    
Collaboration and license revenue $ 8,258 $ 2,359
Operating expenses:    
Research and development 58,813 39,858
Selling, general and administrative 14,751 9,005
Total operating expenses 73,564 48,863
Loss from operations (65,306) (46,504)
Interest and other income (expense), net 332 (409)
Net loss (64,974) (46,913)
Net loss attributable to Portola $ (64,974) $ (46,913)
Net loss per share attributable to Portola common stockholders:    
Basic and diluted $ (1.15) $ (0.95)
Shares used to compute net loss per share attributable to Portola common stockholders:    
Basic and diluted 56,397,881 49,527,850