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Stock-Based Compensation - Additional Information (Detail) - USD ($)
3 Months Ended 12 Months Ended 14 Months Ended
Dec. 31, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2013
Jun. 30, 2015
Jan. 31, 2015
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock reserved, shares 1,422,745 1,422,745          
Percentage increase in number of common stock outstanding   5.00%          
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan 9,387,452 9,387,452          
Term of stock options granted   10 years          
Vesting period   4 years          
Aggregate intrinsic value of stock options exercised   $ 35,900,000 $ 12,500,000   $ 6,300,000    
Total estimated grant date fair value of stock options vested   12,000,000 $ 9,000,000 $ 3,800,000      
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 42,400,000 $ 42,400,000          
Unamortized share based compensation expected recognition period   2 years 9 months 18 days          
Weighted-average per share fair value of employee stock options granted   $ 22.84 $ 15.73 $ 12.46      
Stock-based compensation expense   $ 22,858,000 $ 9,333,000 $ 4,974,000      
Share based compensation, options weighted average exercise price   $ 38.33          
Employee Stock Purchase Plan              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock reserved, shares 1,759,270 1,759,270          
Percentage increase in number of common stock outstanding   2.00%          
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan 1,818,314 1,818,314          
Exercise price of stock options granted as a minimum percentage of fair value of common stock   85.00%          
Dividend yield   0.00% 0.00% 0.00%      
Incentive Stock Options              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Exercise price of stock options granted as a minimum percentage of fair value of common stock   100.00%          
Nonstatutory Stock Options              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Exercise price of stock options granted as a minimum percentage of fair value of common stock   85.00%          
10% or more              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Exercise price of stock options granted as a minimum percentage of fair value of common stock   110.00%          
Percentage of voting stock   10.00%          
Restricted Stock Units (RSUs)              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Vesting period   3 years          
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 3,300,000 $ 3,300,000          
Unamortized share based compensation expected recognition period   2 years          
RSUs Vested during the year   0          
Stock-based compensation expense   $ 1,500,000          
Performance-based RSUs awarded based on achievement of development goals   187,200          
Performance Shares              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan           165,000 165,000
Vesting period   4 years          
Unamortized share based compensation expected to be recognized over the remaining vesting period $ 3,300,000 $ 3,300,000          
Unamortized share based compensation expected recognition period   1 year 4 months 24 days          
RSUs Vested during the year   0          
Stock-based compensation expense   $ 2,300,000          
Number of common stock earned per share   1.00%          
Vesting rights   At any time during the four years following the date of the grant, a portion of the M-PSUs will vest one year after the date the average closing price of our Common Stock on the NASDAQ Global Select Market is above $50.00 per share for 45 consecutive trading days, and the remaining portion of the grant will vest one year after the date the average closing price of our Common Stock is above $60.00 per share for 45 consecutive trading days          
Consecutive trading period required to earn PSU   45 days          
Performance-based RSUs awarded based on achievement of development goals 40,496 165,000          
Dividend yield   0.00%          
Performance Shares | Maximum              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Performance-based RSUs awarded based on achievement of development goals, available for grant           69,625  
Performance Shares | $50 Vesting Hurdle              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Minimum average market closing price to earn M-PSU   $ 50.00          
Performance Shares | $60 Vesting Hurdle              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Minimum average market closing price to earn M-PSU   $ 60.00          
Nonemployee Stock Options              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Vesting period   4 years          
Share based compensation, options granted   66,041 33,888 32,943      
Share based compensation, options weighted average exercise price   $ 40.85 $ 25.41 $ 19.88      
Stock-based compensation   $ 2,790,000 $ 769,000 $ 775,000