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Commercial Supply Agreement - Additional Information (Detail) (USD $)
1 Months Ended 3 Months Ended
Jul. 31, 2014
Mar. 31, 2015
Dec. 31, 2014
Nov. 01, 2014
Long Term Purchase Commitment [Line Items]        
Prepaid and other long-term assets   $ 14,678,000us-gaap_PrepaidExpenseAndOtherAssetsNoncurrent $ 15,612,000us-gaap_PrepaidExpenseAndOtherAssetsNoncurrent  
CMC ICOS Biologics Inc        
Long Term Purchase Commitment [Line Items]        
Commercial supply agreement upfront payment 10,000,000ptla_CommercialSupplyAgreementUpfrontPayment
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
     
Commercial supply (manufacturing services) agreement reservation payment       4,600,000ptla_CommercialSupplyAgreementReservationPayment
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
Commercial agreement fixed commitment amount 293,900,000us-gaap_LongTermPurchaseCommitmentAmount
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
     
Payments related to commercial supply agreement   6,400,000ptla_PaymentsRelatedToCommercialSupplyAgreement
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
   
Term of commercial supply agreement   7 years    
CMC ICOS Biologics Inc | Upfront Fee        
Long Term Purchase Commitment [Line Items]        
Prepaid and other long-term assets   14,600,000us-gaap_PrepaidExpenseAndOtherAssetsNoncurrent
/ us-gaap_DeferredRevenueArrangementTypeAxis
= ptla_UpfrontFeeMember
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
   
CMC ICOS Biologics Inc | Minimum        
Long Term Purchase Commitment [Line Items]        
Termination fees payment under obligation 5,000,000us-gaap_LossOnContractTerminationForDefault
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
/ us-gaap_RangeAxis
= us-gaap_MinimumMember
     
CMC ICOS Biologics Inc | Maximum        
Long Term Purchase Commitment [Line Items]        
Termination fees payment under obligation $ 30,000,000us-gaap_LossOnContractTerminationForDefault
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CMCICOSBiologicsIncMember
/ us-gaap_RangeAxis
= us-gaap_MaximumMember