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Stock Options Outstanding and Vested and Exercisable (Detail) (USD $)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]    
Options Outstanding, Number of Options Outstanding 4,249,168us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber 3,708,773us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
Outstanding 6 years 7 months 6 days  
Outstanding $ 14.77us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice $ 9.43us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
Options Vested, Number of Options Vested 2,503,676us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares  
Options Vested, Weighted Average Exercise Price Per Share $ 9.67ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedWeightedAverageExercisePrice  
$1.00 - $5.10    
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]    
Exercise Prices, Lower Limit $ 1.00us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeOneMember
 
Exercise Prices, Upper Limit $ 5.10us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeOneMember
 
Options Outstanding, Number of Options Outstanding 945,481us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeOneMember
 
Outstanding 2 years 9 months 18 days  
Outstanding $ 4.21us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeOneMember
 
Options Vested, Number of Options Vested 945,481us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeOneMember
 
Options Vested, Weighted Average Exercise Price Per Share $ 4.21ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeOneMember
 
$5.30 - $9.00    
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]    
Exercise Prices, Lower Limit $ 5.30us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeTwoMember
 
Exercise Prices, Upper Limit $ 9.00us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeTwoMember
 
Options Outstanding, Number of Options Outstanding 1,068,191us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeTwoMember
 
Outstanding 6 years  
Outstanding $ 8.07us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeTwoMember
 
Options Vested, Number of Options Vested 927,581us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeTwoMember
 
Options Vested, Weighted Average Exercise Price Per Share $ 8.21ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeTwoMember
 
$9.50 - $23.85    
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]    
Exercise Prices, Lower Limit $ 9.50us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeThreeMember
 
Exercise Prices, Upper Limit $ 23.85us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeThreeMember
 
Options Outstanding, Number of Options Outstanding 976,963us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeThreeMember
 
Outstanding 8 years 2 months 12 days  
Outstanding $ 17.61us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeThreeMember
 
Options Vested, Number of Options Vested 406,830us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeThreeMember
 
Options Vested, Weighted Average Exercise Price Per Share $ 16.81ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeThreeMember
 
$24.39 - $26.67    
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]    
Exercise Prices, Lower Limit $ 24.39us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFourMember
 
Exercise Prices, Upper Limit $ 26.67us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFourMember
 
Options Outstanding, Number of Options Outstanding 861,050us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFourMember
 
Outstanding 8 years 7 months 6 days  
Outstanding $ 25.13us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFourMember
 
Options Vested, Number of Options Vested 178,702us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFourMember
 
Options Vested, Weighted Average Exercise Price Per Share $ 25.04ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFourMember
 
$26.75 - $29.19    
Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items]    
Exercise Prices, Lower Limit $ 26.75us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFiveMember
 
Exercise Prices, Upper Limit $ 29.19us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFiveMember
 
Options Outstanding, Number of Options Outstanding 397,483us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFiveMember
 
Outstanding 9 years 6 months  
Outstanding $ 28.42us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFiveMember
 
Options Vested, Number of Options Vested 45,082us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFiveMember
 
Options Vested, Weighted Average Exercise Price Per Share $ 29.02ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedWeightedAverageExercisePrice
/ us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis
= ptla_RangeFiveMember