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Stock-Based Compensation - Additional Information (Detail) (USD $)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]      
Common stock reserved, shares 935,213us-gaap_CommonStockCapitalSharesReservedForFutureIssuance    
Term of stock options granted   10 years  
Vesting period of stock options 2 years 9 months 18 days 4 years  
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan 6,949,108us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized    
Aggregate intrinsic value of options exercised $ 12,500,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue $ 6,300,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue $ 451,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
Total estimated grant date fair value of options vested 9,000,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1 3,800,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1 3,000,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1
Unamortized share based compensation expected to be recognized over the remaining vesting period 21,800,000us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized    
Weighted-average per share fair value of employee options granted $ 15.73us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue $ 12.46us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue $ 5.90us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
Share based compensation, options weighted average exercise price $ 25.96us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice    
Incentive Stock Options      
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]      
Exercise price of stock options granted as a minimum percentage of fair value of common stock   100.00%us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent
/ us-gaap_AwardTypeAxis
= ptla_IncentiveStockOptionsMember
 
Nonstatutory Stock Options      
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]      
Exercise price of stock options granted as a minimum percentage of fair value of common stock   85.00%ptla_StockOptionGrantsExercisePriceMinimumPercentageOnFairMarketValue
/ us-gaap_AwardTypeAxis
= ptla_NonstatutoryStockOptionsMember
 
10% or more      
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]      
Exercise price of stock options granted as a minimum percentage of fair value of common stock   110.00%ptla_StockOptionGrantsExercisePriceMinimumPercentageOnFairMarketValue
/ us-gaap_AwardTypeAxis
= ptla_TenPercentOrMoreStockholdersMember
 
Percentage of voting stock   10.00%ptla_PercentageOfVotingStock
/ us-gaap_AwardTypeAxis
= ptla_TenPercentOrMoreStockholdersMember
 
Nonemployee Stock Options      
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]      
Vesting period of stock options 4 years    
Share based compensation, options granted 33,888us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
32,943us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
6,380us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
Share based compensation, options weighted average exercise price $ 25.41us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
$ 19.88us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
$ 7.00us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
Stock-based compensation $ 769,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
$ 775,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
$ 144,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_AwardTypeAxis
= ptla_NonEmployeeStockOptionMember
Employee Stock Purchase Plan      
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]      
Exercise price of stock options granted as a minimum percentage of fair value of common stock 85.00%us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockMember
   
Number of common stock shares reserved for issuance under the 2013 Employee Stock Purchase Plan 1,000,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockMember
   
Percentage increase in number of common stock outstanding 2.00%ptla_ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseInSharesAvailableForIssuancePercentageOfCommonStockOutstanding
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockMember