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Commercial Supply Agreements - Additional Information (Detail) (CMC ICOS Biologics Inc, USD $)
In Millions, unless otherwise specified
1 Months Ended 12 Months Ended
Jul. 31, 2014
Dec. 31, 2014
Nov. 01, 2014
Long Term Purchase Commitment [Line Items]      
Commercial supply agreement upfront payment $ 10.0ptla_CommercialSupplyAgreementUpfrontPayment $ 14.6ptla_CommercialSupplyAgreementUpfrontPayment  
Commercial supply (manufacturing services) agreement reservation payment     4.6ptla_CommercialSupplyAgreementReservationPayment
Commercial agreement fixed commitment amount 293.9us-gaap_LongTermPurchaseCommitmentAmount    
Payments related to commercial supply agreement   2.6ptla_PaymentsRelatedToCommercialSupplyAgreement  
Minimum
     
Long Term Purchase Commitment [Line Items]      
Termination fees payment under obligation 16.0us-gaap_LossOnContractTerminationForDefault
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CmcIcosBiologicsIncMember
/ us-gaap_RangeAxis
= us-gaap_MinimumMember
   
Maximum
     
Long Term Purchase Commitment [Line Items]      
Termination fees payment under obligation $ 30.0us-gaap_LossOnContractTerminationForDefault
/ us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis
= ptla_CmcIcosBiologicsIncMember
/ us-gaap_RangeAxis
= us-gaap_MaximumMember