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Accrued Expenses (Detail) (USD $)
In Thousands, unless otherwise specified
Jun. 30, 2014
Dec. 31, 2013
Accounts Payable And Accrued Liabilities [Line Items]    
Research and development related $ 18,343 $ 16,110
Legal and accounting fees 413 462
Deferred rent 81 879
Other 478 345
Total accrued liabilities $ 19,315 $ 17,796