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			&lt;p style="margin:0pt; page-break-after:avoid"&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; font-weight:bold"&gt;1. Organization &lt;/font&gt;&lt;/p&gt;
			&lt;p style="margin:6pt 0pt 0pt"&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Portola Pharmaceuticals, Inc. (the &amp;#8220;Company&amp;#8221; or &amp;#8220;we&amp;#8221; or &amp;#8220;our&amp;#8221; or &amp;#8220;us&amp;#8221;) is a biopharmaceutical company focused on the development and commercialization of novel therapeuti&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;cs in the areas of thrombosis, other hematologic disorders and inflammation for patients who currently have limited or no approved treatment options. We were incorporated in September 2003 in Delaware. Our headquarters and operations are located in South San Francisco, California and we operate in &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;one&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; segment. &lt;/font&gt;&lt;/p&gt;
			&lt;p style="margin:12pt 0pt 0pt"&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Our two lead programs address the area of thrombosis, or blood clots. Our lead compound &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Betrixaban&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; is a novel oral once-daily inhibitor of Factor &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Xa&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; in Phase 3 development for extended duration prophylaxis, or preventive treatment, of a form of thrombosis known as venous thromboembolism, in acute medically ill patients. Our second lead development candidate &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;(&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;pINN&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;) &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Andexanet&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;al&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;f&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;a&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; is a recombinant protein designed to reverse the anticoagulant activity in patients treated with a Factor &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Xa&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; inhibitor who suffer an uncontrolled bleeding episode or undergo emergency surgery. Our third product candidate, PRT2070, is an orally available kinase inhibitor being developed for hematologic, or blood, cancers and inflammatory disorders. Our fourth program, PRT2607 and other selective &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Syk&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; inhibitors, is &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;being developed in partnership &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;with &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;Biogen&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; Idec Inc. &lt;/font&gt;&lt;/p&gt;
			&lt;p style="margin:14pt 0pt 0pt; page-break-after:avoid"&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; font-weight:bold"&gt;Initial Public Offering &lt;/font&gt;&lt;/p&gt;
			&lt;p style="margin:6pt 0pt 0pt"&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;In &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;May&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;&amp;#160;&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;2013, the Company closed its initial public offering (&amp;#8220;IPO&amp;#8221;) of &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;9,686,171&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; shares of its common stock, which included &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;1,263,413&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; shares of common stock issued pursuant to the over-allotment option granted to &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;our &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;underwriters. The public offering price of the shares sold in the offering was $&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;14.50&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; per share. The total proceeds from the offering to the Company, net of underwriting discounts and commissions of approximately $&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;9.4&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; million, were approximately $&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;131.0&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; million. After deducting offering expenses payable by us of approximately $&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;5.&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;2&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; million, &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;net proceeds to the company were&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; $&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;125.8&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; million. As of June&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;&amp;#160;&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;30, 2013, $&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;2.1&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; million of accrued offering costs remained unpaid and these costs are expected to be paid by the end of the Company&amp;#8217;s fiscal year. Upon the closing of the IPO, all shares of convertible preferred stock&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; then&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; outstanding converted into &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt; "&gt;24,026,797&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; shares of common stock.&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; In addition, all &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;of our &lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;convertible preferred stock warrants were converted into warrants&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; to purchase common stock&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt;.&lt;/font&gt;&lt;font style="font-family:&amp;apos;Times New Roman&amp;apos;; font-size:10pt"&gt; &lt;/font&gt;&lt;/p&gt;
		&lt;/div&gt;</NonNumbericText><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat></Cell></Cells><ElementDataType>nonnum:textBlockItemType</ElementDataType><SimpleDataType>na</SimpleDataType><ElementDefenition>The entire disclosure for the nature of an entity's business, the major products or services it sells or provides and its principal markets, including the locations of those markets. If the entity operates in more than one business, the disclosure also indicates the relative importance of its operations in each business and the basis for the determination (for example, assets, revenues, or earnings).</ElementDefenition><ElementReferences>Reference 1: http://www.xbrl.org/2003/role/presentationRef

 -Publisher FASB

 -Name Accounting Standards Codification

 -Topic 275

 -SubTopic 10

 -Section 50

 -Paragraph 2

 -URI http://asc.fasb.org/extlink&amp;oid=6927468&amp;loc=d3e6003-108592



Reference 2: http://www.xbrl.org/2003/role/presentationRef

 -Publisher AICPA

 -Name Statement of Position (SOP)

 -Number 94-6

 -Paragraph 10

 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009.  This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.



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