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Collaboration and License Agreements - Additional Information (Detail) (USD $)
3 Months Ended 6 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Nov. 30, 2012
Biogen Idec
Jun. 30, 2013
Biogen Idec
Jun. 30, 2012
Biogen Idec
Jun. 30, 2013
Biogen Idec
Jun. 30, 2012
Biogen Idec
Sep. 30, 2013
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer")
Jun. 30, 2013
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer")
Collaborative Arrangement
Jun. 30, 2012
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer")
Collaborative Arrangement
Jun. 30, 2013
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer")
Collaborative Arrangement
Jun. 30, 2012
Bristol-Myers Squibb Company ("BMS") and Pfizer Inc. ("Pfizer")
Collaborative Arrangement
Jan. 31, 2013
Lee's Pharmaceutical (HK) Ltd ("Lee's")
Jun. 30, 2013
Lee's Pharmaceutical (HK) Ltd ("Lee's")
Collaborative Arrangement
Jun. 30, 2013
Lee's Pharmaceutical (HK) Ltd ("Lee's")
Collaborative Arrangement
Jun. 30, 2013
Aciex Therapeutics, Inc. (Aciex)
Jun. 30, 2013
Aciex Therapeutics, Inc. (Aciex)
Feb. 01, 2013
Bayer Pharma AG
Feb. 01, 2013
Janssen Pharmaceuticals, Inc.
Feb. 01, 2013
Bayer Pharma, AG ('Bayer") and Janssen Pharmaceuticals, Inc. ("Janssen")
Jun. 30, 2013
Bayer Pharma, AG ('Bayer") and Janssen Pharmaceuticals, Inc. ("Janssen")
Collaborative Arrangement
Jun. 30, 2012
Bayer Pharma, AG ('Bayer") and Janssen Pharmaceuticals, Inc. ("Janssen")
Collaborative Arrangement
Jun. 30, 2013
Bayer Pharma, AG ('Bayer") and Janssen Pharmaceuticals, Inc. ("Janssen")
Collaborative Arrangement
Jun. 30, 2012
Bayer Pharma, AG ('Bayer") and Janssen Pharmaceuticals, Inc. ("Janssen")
Collaborative Arrangement
Jun. 30, 2013
Daiichi Sankyo, Inc. ("Daiichi")
Jun. 30, 2013
Daiichi Sankyo, Inc. ("Daiichi")
Collaborative Arrangement
Jun. 30, 2013
PORTOLA PHARMACEUTICALS INC
Research And Development Arrangement Contract To Perform For Others [Line Items]                                                          
License fee receivable upon occurrence of certain development and regulatory events         $ 370,000,000                                                
Notice period for agreement termination         120 days                   60 days                            
Reduction in research and development expense           164,000 2,100,000 494,000 4,800,000                                        
Deferred revenue                   6,000,000 900,000   900,000     648,000 648,000           2,600,000   2,600,000     2,900,000  
Collaboration revenue recognized                     1,100,000    3,100,000      52,000 52,000           1,300,000    2,400,000      125,000  
Upfront and non-refundable fee                             700,000         2,500,000 2,500,000 5,000,000              
Development costs, percent                                     60.00%                   40.00%
Research and development 20,833,000 13,088,000 38,556,000 26,049,000                           0 0                    
Additional upfront and non-refundable fee                                       250,000 250,000 500,000              
Collaborative arrangement up front payment to be received                                                     6,000,000    
Upfront fee subject to refund                                                     3,000,000    
Contingent consideration of collaboration arrangement                                                       3,000,000  
Non-contingent consideration being recognized as revenue over estimated period of performance                                                       $ 3,000,000