X0306 4 2019-04-15 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001187333 RENTON HOLLINGS C/O PORTOLA PHARMACEUTICALS, INC. 270 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2019-04-15 4 M 0 5000 9.00 A 14000 D Common Stock 2019-04-15 4 S 0 4600 34.3962 D 9400 D Common Stock 2019-04-15 4 S 0 400 35.0675 D 9000 D Common Stock 2826 I Held by The Renton Family Community Property Trust Stock Options (Right to Buy) 9.00 2019-04-15 4 M 0 5000 0.00 D 2020-04-27 Common Stock 5000 15000 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2019. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.9700 to $34.9650, inclusive. The reporting person undertakes to provide Portola Pharmaceuticals, Inc., any security holder of Portola Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2) - (3) to this Form 4. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.0000 to $35.1800, inclusive. The reporting person undertakes to provide Portola Pharmaceuticals, Inc., any security holder of Portola Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2) - (3) to this Form 4. The option, representing a right to purchase a total of 20,000 shares, became exercisable monthly over a two year period beginning on May 29, 2010. /s/ Mike Ouimette, as attorney-in-fact 2019-04-16