X0306 4 2015-06-30 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001574558 Lis William C/O PORTOLA PHARMACEUTICALS, INC. 270 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Executive Officer Common Stock 2015-06-30 4 M 0 15000 7.00 A 15000 D Common Stock 2015-06-30 4 S 0 5400 44.026 D 9600 D Common Stock 2015-06-30 4 S 0 9600 44.73 D 0 D Common Stock 2015-07-01 4 M 0 15000 7.00 A 15000 D Common Stock 2015-07-01 4 S 0 14900 45.536 D 100 D Common Stock 2015-07-01 4 S 0 100 46.07 D 0 D Stock Option (Right to Buy) 7.00 2015-06-30 4 M 0 15000 0.00 D 2012-03-08 2022-03-08 Common Stock 15000 64386 D Stock Option (Right to Buy) 7.00 2015-07-01 4 M 0 15000 0.00 D 2012-03-08 2022-03-08 Common Stock 15000 49386 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 16, 2015. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $43.44 to $44.43, inclusive. The reporting person undertakes to provide Portola Pharmaceuticals, Inc., any security holder of Portola Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2), (3), (4), and (5) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.44 to $45.17, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.94 to $45.89, inclusive. These shares were sold in a single transaction at a price of $46.07. /s/ Mardi Dier, as attorney-in-fact 2015-07-01