X0306 4 2015-05-11 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001187333 RENTON HOLLINGS C/O PORTOLA PHARMACEUTICALS, INC. 270 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2015-05-11 4 M 0 520 7.00 A 520 D Common Stock 2015-05-11 4 M 0 5000 7.00 A 5520 D Common Stock 2015-05-11 4 M 0 5000 7.00 A 10520 D Common Stock 2015-05-11 4 S 0 10520 38.325 D 0 D Stock Option (Right to Buy) 7.00 2015-05-11 4 M 0 520 0.00 D 2011-12-15 2021-12-15 Common Stock 520 0 D Stock Option (Right to Buy) 7.00 2015-05-11 4 M 0 5000 0.00 D 2011-12-15 2021-12-15 Common Stock 5000 0 D Stock Option (Right to Buy) 7.00 2015-05-11 4 M 0 5000 0.00 D 2012-09-25 2022-09-25 Common Stock 5000 0 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.30 to $38.355, inclusive. The reporting person undertakes to provide Portola Pharmaceuticals, Inc., any security holder of Portola Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this Form 4. /s/ Nanci Salvucci, as attorney-in-fact 2015-05-11