X0306 4 2014-06-16 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001574589 Curnutte John T C/O PORTOLA PHARMACEUTICALS, INC. 270 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Executive Vice President Common Stock 2014-06-16 4 M 0 10000 8.50 A 10000 D Common Stock 2014-06-16 4 S 0 10000 25.997 D 0 D Employee Stock Option (right to buy) 8.50 2014-06-16 4 M 0 10000 0.00 D 2011-03-23 2021-03-23 Common Stock 10000 203682 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 28, 2014. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.66 to $26.23, inclusive. The reporting person undertakes to provide to Portola Pharmaceuticals, Inc., any security holder of Portola Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4. /s/ Mike Ouimette, as attorney-in-fact 2014-06-16