X0306 4 2014-03-26 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001574558 Lis William C/O PORTOLA PHARMACEUTICALS, INC. 270 E. GRAND AVENUE, SUITE 22 SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Executive Officer Stock Option (Right to Buy) 25.08 2014-03-26 4 A 0 130000 A 2024-03-25 Common Stock 130000 130000 D The Option shares shall vest as follows: 1/48th of the shares subject to such option shall vest each month after January 1, 2014, subject to Reporting Person's Continuous Service ( as defined in the Issuer's 2013 Equity Incentive Plan) as of each such date. Not applicable. /s/ Sally A. Kay, as attorney-in-fact 2014-03-27