X0306 4 2014-03-25 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001574591 Dier Mardi C/O PORTOLA PHARMACEUTICALS, INC. 270 EAST GRAND AVENUE, SUITE 22 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Senior VP and CFO Common Stock 2014-03-25 4 S 0 5000 25.6866 D 29824 D Stock Option (Right to Buy) 25.08 2014-03-26 4 A 0 75000 A 2024-03-25 Common Stock 75000 75000 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 3, 2014. The Option shares shall vest as follows: 1/48th of the shares subject to such option shall vest each month after January 1, 2014, subject to Reporting Person's Continuous Service (as defined in the Issuer's 2013 Equity Incentive Plan) as of each such date. Not applicable. /s/ Sally A. Kay, as attorney-in-fact 2014-03-27