X0306 4 2013-11-06 0 0001269021 PORTOLA PHARMACEUTICALS INC PTLA 0001574591 Dier Mardi C/O PORTOLA PHARMACEUTICALS, INC. 270 EAST GRAND AVENUE, SUITE 22 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Senior VP and CFO Common Stock 34824 D Stock Option (Right to Buy) 22.06 2013-11-06 4 A 0 75000 A 2023-11-05 Common Stock 75000 75000 D Since the date of the reporting person's last ownership report, she transferred 34,825 shares of PTLA common stock and employee stock options to purchase 51,951 shares of PTLA common stock to her ex-husband pursuant to a domestic relations order. The reporting person no longer reports as beneficially owned any securities owned by her ex-husband. The Option shares shall vest as follows: one-fourth (1/4th) of the shares vest one year after November 1, 2013; the balance of the shares vest in a series of thirty-six (36) successive equal monthly installments measured from the first anniversary of November 1, 2013, subject to Reporting Person's Continuous Service (as defined in the Issuer's 2013 Equity Incentive Plan) as of each such date. Not applicable. /s/ Sally A. Kay, Attorney-In-Fact 2013-11-06