Income Taxes - Other (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Loss before income taxes
U.S. operations	$ 142,943	$ 16,427
Loss before income taxes	142,943	16,427
U.S. State	(1,538)	2,445
Foreign		944
Gross deferred tax assets:
Net operating loss carryforwards	72,792	58,056
Accrued expenses	1,754	124
Amortization of intangible	468	454
Stock-based compensation	8,741	8,091
Research and development and other credits and other carryforwards	39,588	30,627
Lease liability	345	440
Capitalized research and development expenses	37,643	22,382
Royalty/ Deferred Revenue	4,298	3,781
Capital Loss	74	94
Interest carryforward	2,152
Other	152	64
Total gross deferred tax assets	168,007	124,113
Gross deferred tax liabilities:
ROU Asset	(237)	(291)
Depreciation	(458)	(224)
Unrealized income	(209)	(192)
Total gross deferred tax liabilities	(904)	(707)
Net deferred tax assets	167,103	123,406
Less: valuation allowance	(167,103)	(123,406)
Increase (decrease) in valuation allowance	43,700	7,700
Unrecognized tax benefits	0	0
Liability for uncertain tax positions	0	0
Interest and penalties accrued related to unrecognized tax benefits	0	0
Income tax benefit	$ 1,538	$ (3,389)
Reconciliation of income tax expense (benefit) at the statutory federal income tax rate and income taxes
Federal income tax expense at statutory rate (as a percent)	21.00%	21.00%
Permanent items (as a percent)	(0.40%)	(2.60%)
State income tax, net of federal benefit (as a percent)	4.10%	(9.00%)
R&D tax credits (as a percent)	6.30%	88.10%
Change in state apportionment (as a percent)	2.50%	(59.50%)
Foreign withholding tax (as a percent)		(5.70%)
Change in valuation allowance (as a percent)	(30.60%)	(47.00%)
Other (as a percent)	(1.80%)	(5.90%)
Effective income tax rate (as a percent)	1.10%	(20.60%)
Federal
Loss before income taxes
Net operating loss carry forwards available to offset future federal and state taxable income	$ 292,200	$ 233,500
Net operating loss carry forwards subject to expiration	81,100
State
Loss before income taxes
Net operating loss carry forwards available to offset future federal and state taxable income	240,100	204,600
Tax credit carryovers	400
Collaboration Agreement with Tenacia
Loss before income taxes
Foreign		900
Research and development
Loss before income taxes
U.S. State		$ 2,400
Research and development | Federal
Loss before income taxes
Tax credit carryovers	$ 39,200