CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Series A Convertible Preferred Stock Preferred Stock	Common Stock	Additional Paid-in Capital	Treasury Stock	Accumulated Other Comprehensive Income	Accumulated Deficit	Total
Balance Beginning at Dec. 31, 2021	$ 4,302	$ 37	$ 459,852			$ (410,705)	$ 53,486
Balance Beginning (in shares) at Dec. 31, 2021	4,575	36,790,254		7,307
Increase (Decrease) in Stockholders' Equity (Deficit)
Stock-based compensation expense			14,890				14,890
Issuance of common stock and pre-funded warrants		$ 13	64,464				64,477
Issuance of common stock and pre-funded warrants (in shares)		12,421,053
Exercise of stock options			1,794				1,794
Exercise of stock options (in shares)		238,312
Net issuance of common stock in connection with the vesting of restricted stock (in shares)		14,893
Issuance of stock related to IP license agreement with Ovid			1,169				$ 1,169
Issuance of stock related to IP license agreement with Ovid (in shares)		123,255
Conversion of convertible preferred stock into common	$ (259)		259
Conversion of convertible preferred stock into common stock (in shares)	(275)	55,000
Issuance of common stock in connection with at-the-market facility offering (average price of $7.17 per share), net of expenses of $529 (in shares)							0
Net Income (Loss)						(19,816)	$ (19,816)
Balance Ending at Dec. 31, 2022	$ 4,043	$ 50	542,428			(430,521)	116,000
Balance Ending (in shares) at Dec. 31, 2022	4,300	49,642,767		7,307
Increase (Decrease) in Stockholders' Equity (Deficit)
Stock-based compensation expense			15,563				15,563
Exercise of stock options			804				804
Exercise of stock options (in shares)		126,735
Net issuance of common stock in connection with the vesting of restricted stock (in shares)		258,819
Conversion of convertible preferred stock into common	$ (4,043)	$ 1	4,042
Conversion of convertible preferred stock into common stock (in shares)	(4,300)	860,000
Issuance of common stock in connection with at-the-market facility offering (average price of $7.17 per share), net of expenses of $529		$ 4	25,819				25,823
Issuance of common stock in connection with at-the-market facility offering (average price of $7.17 per share), net of expenses of $529 (in shares)		3,689,800
Unrealized loss on short-term investments					$ (20)		(20)
Net Income (Loss)						(141,405)	(141,405)
Balance Ending at Dec. 31, 2023		$ 55	$ 588,656		$ (20)	$ (571,926)	$ 16,765
Balance Ending (in shares) at Dec. 31, 2023		54,578,121		7,307