Stockholders' Equity - Other (Details) - USD ($) $ / shares in Units, $ in Thousands		3 Months Ended		9 Months Ended		12 Months Ended
	Mar. 29, 2022	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022	Jan. 01, 2023
Stockholders' Equity
Total compensation cost		$ 4,006	$ 3,895	$ 11,638	$ 11,091
Maximum percentage of beneficial ownership for exercise of Pre-funded Warrants						9.99%
Maximum percentage increase or decrease of beneficial ownership for exercise of Pre-funded Warrants						19.99%
Public Offering.
Stockholders' Equity
Stock Issued During Period, Shares, New Issues						12,421,053
Number of pre-funded warrants (in shares)						2,105,264
Proceeds from equity offerings, net of offering costs						$ 64,500
Research and development.
Stockholders' Equity
Total compensation cost		1,519	1,394	4,329	4,069
Selling, general and administrative
Stockholders' Equity
Total compensation cost		$ 2,487	$ 2,501	$ 7,309	$ 7,022
Ovid License Agreement
Stockholders' Equity
Stock Issued During Period, Shares, New Issues	123,255
Series A Convertible Preferred Stock
Shares
Conversion of Series A Convertible Preferred Stock (in shares)				4,300
Preferred stock, shares outstanding		0		0		4,300
Common Stock
Shares
Shares issued in the conversion of Series A Convertible Preferred Stock to common stock (in shares)				860,000
Stock option
Stock Options
Outstanding (in shares)		7,188,661		7,188,661
Outstanding, weighted-average exercise price (in dollars per share)		$ 9.75		$ 9.75
Granted (in shares)				1,971,291
Granted (in dollars per share)				$ 6.34
Restricted common stock
Stockholders' Equity
Vesting period				2 years
2005 Plan
Stockholders' Equity
Common stock reserved for issuance (in shares)		0		0
2005 Plan | Stock option
Stock Options
Outstanding (in shares)		577		577
2014 Plan
Stockholders' Equity
Common stock reserved for issuance (in shares)		775,794		775,794			2,020,111
2014 Plan | Stock option
Stock Options
Outstanding (in shares)		5,063,925		5,063,925
Granted (in shares)				1,550,766
2014 Plan | Restricted Stock Units
Stockholders' Equity
Vesting period				3 years
Shares
Issued (in shares)				974,940
Restricted shares of common stock outstanding (in shares)		1,265,316		1,265,316
Equity Incentive Plan, Employee Inducements | Stock option
Stock Options
Outstanding (in shares)		2,124,159		2,124,159
Granted (in shares)				420,525