CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities
Net loss	$ (34,730)	$ (19,361)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	157	85
Amortization of debt issuance costs	480	282
Accretion of revenue interest financing debt	1,440
Stock-based compensation expense	3,741	3,378
Amortization of net contract asset/liability	(413)	(375)
Noncash lease expense	53	80
Noncash lease liability	96	69
Write off of fixed assets	62	61
Issuance of common stock for cost of license agreement		1,169
Unrealized loss (gain) on foreign currency transactions		930
Amortization of discount on short-term investments	(228)
Changes in operating assets and liabilities:
Refund liability		(22,163)
Net contract asset/liability	544	10,045
Prepaid expenses and other current assets, non-current assets, inventory and accounts receivable	(8,963)	(1,072)
Accounts payable and accrued expenses	(3,717)	(783)
Net cash used in operating activities	(41,478)	(27,655)
Cash flows from investing activities
Purchases of short-term investments	(51,995)
Purchases of property and equipment		(86)
Net cash provided by (used in) investing activities	(51,995)	(86)
Cash flows from financing activities
Proceeds from exercise of stock options		1,733
Proceeds from notes payable, net of fees		29,400
Payments of revenue interesting financing debt	(174)
Net cash provided by financing activities	(174)	31,133
Net (decrease) increase in cash and cash equivalents	(93,647)	3,392
Cash and cash equivalents-beginning of period	240,551	122,927
Cash and cash equivalents-end of period	146,904	126,319
Supplemental disclosure of cash flow information
Unrealized gain on short-term investments	74
Debt issuance costs included in accrued expenses		563
Property and equipment in accrued expenses		205
Cash paid for interest during the year	$ 2,156
Property and equipment in deposits placed in service		$ 337