Collaboration Revenue - Allocation of the transaction price to the performance obligations (Details) $ in Thousands, € in Millions			3 Months Ended	12 Months Ended
	Jul. 30, 2021 USD ($) item	Jul. 30, 2021 EUR (€) item	Mar. 31, 2023 USD ($)	Dec. 31, 2022 USD ($) item
License and Collaboration Revenue
Net Contract Liability			$ 16,416	$ 16,285
Collaboration Agreement with Orion
License and Collaboration Revenue
Collaboration revenue				12,700
Number of performance obligations | item	3	3
Transaction Price			37,880	37,880
Cumulative Collaboration Revenue Recognized			23,231	22,818
Contract Liability			14,649	15,062
Less Total Contract Asset			4,535	5,079
Net Contract Liability			10,114	9,983
Incremental costs incurred in obtaining the agreement			2,000
Capitalized contract costs			900
Upfront fee received	$ 29,600	€ 25.0
Collaboration Agreement with Orion | Selling, general and administrative
License and Collaboration Revenue
Contract acquisition costs included in general and administrative expense			1,100
Collaboration Agreement with Orion | License Revenue
License and Collaboration Revenue
Transaction Price			21,660	21,660
Cumulative Collaboration Revenue Recognized			21,660	21,660
Collaboration Agreement with Orion | Development and Regulatory Services
License and Collaboration Revenue
Amortization of transaction price as a reduction of research and development costs			400	1,100
Transaction Price			6,717	6,717
Cumulative Collaboration Revenue Recognized			1,571	1,158
Contract Liability			5,146	5,559
Collaboration Agreement with Orion | Supply of License Product
License and Collaboration Revenue
Transaction Price			9,503	9,503
Contract Liability			9,503	$ 9,503
Collaboration Agreement with Tenacia
License and Collaboration Revenue
Number of performance obligations | item				2
Number of commitments represent distinct performance | item				2
Transaction Price			10,000
Cumulative Collaboration Revenue Recognized			2,998
Contract Liability			7,002	$ 7,000
Less Total Contract Asset			700	700
Net Contract Liability			6,302	6,300
Cost of revenue			200
Incremental costs incurred in obtaining the agreement			1,000
Capitalized contract costs			700
Upfront fee received				10,000
Aggregate amount				256,000
Milestone regulatory approvals				15,000
Aggregative sales based milestone				241,000
Collaboration Agreement with Tenacia | Selling, general and administrative
License and Collaboration Revenue
Contract acquisition costs included in general and administrative expense			100
Collaboration Agreement with Tenacia | License Revenue
License and Collaboration Revenue
Collaboration revenue			0
Transaction Price			2,998	$ 3,000
Cumulative Collaboration Revenue Recognized			2,998
Collaboration Agreement with Tenacia | Supply of License Product
License and Collaboration Revenue
Transaction Price			7,002
Contract Liability			$ 7,002