CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities
Net loss	$ (19,816)	$ (98,776)
Adjustments to reconcile net loss to net cash used in operating activities:
Gain from sale of PRV, net of transaction costs	(107,375)
Depreciation and amortization	418	355
Amortization of debt issuance costs	1,663	549
Accretion of revenue interest financing debt	956
Stock-based compensation expense	14,890	13,867
Amortization of net contract asset/liability	(1,052)	(105)
Noncash lease expense	251	312
Noncash lease liability	344	309
Write off of fixed assets	828	243
Issuance of common stock for cost of license agreement	1,169
Unrealized loss (gain) on foreign currency transactions	930	(930)
Changes in operating assets and liabilities:
Refund liability	(22,163)	22,163
Net contract asset/liability	17,894	(452)
Prepaid expenses and other current assets, non-current assets, inventory and accounts receivable	(5,577)	(853)
Accounts payable and accrued expenses	3,754	7,841
Net cash used in operating activities	(112,886)	(55,477)
Cash flows from investing activities
Proceeds from sale of PRV, net of transaction costs	107,375
Proceeds from sale of property and equipment	171
Maturities of short-term investments		1,474
Deposit on property and equipment		(1,793)
Purchases of property and equipment	(1,774)	(1,096)
Net cash provided by (used in) investing activities	105,772	(1,415)
Cash flows from financing activities
Proceeds from exercise of stock options	1,794	1,199
Proceeds from notes payable, net of fees	28,588	40,259
Proceeds from revenue interest financing agreement, net of issuance costs	29,921
Payments of revenue interesting financing debt	(42)
Financing costs, paid		(148)
Proceeds from equity offerings, net of offering costs	64,477
Net cash provided by financing activities	124,738	41,310
Net increase in cash and cash equivalents	117,624	(15,582)
Cash and cash equivalents-beginning of period	122,927	138,509
Cash and cash equivalents-end of period	240,551	122,927
Supplemental disclosure of cash flow information
Debt issuance costs included in accrued expenses		900
Property and equipment in accrued expenses	22	43
Cash paid for interest during the year	7,892	$ 2,032
Property and equipment in deposits placed in service	$ 1,664