Organization and Description of the Business (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended				12 Months Ended
	Dec. 31, 2022	Nov. 30, 2022	Oct. 31, 2022	Aug. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Liquidity
Net loss					$ 19,816	$ 98,776
Accumulated deficit	$ 430,521				$ 430,521	$ 410,705
Warrant exercise price (in dollars per share)	$ 0.001				$ 0.001
Proceeds from sale of PRV, net of transaction costs				$ 107,400	$ 107,375
Public Offering.
Liquidity
Proceeds from equity offerings, net of offering costs	$ 64,500	$ 64,500
Royalty monetization agreement | Sagard Healthcare Partners
Liquidity
Upfront fee received			$ 32,500
Collaboration and supply agreement with Tenacia
Liquidity
Upfront fee received			$ 10,000