Stockholders' Equity (Details) - USD ($) $ / shares in Units, $ in Thousands		3 Months Ended			9 Months Ended
	Mar. 29, 2022	Sep. 30, 2022	Mar. 31, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Jan. 01, 2022	Dec. 31, 2021
Shares
Number of common shares issued for each convertible Series A preferred stock		860,000			860,000
Ovid License Agreement
Stockholders' Equity
Stock Issued During Period, Shares, New Issues	123,255
Series A Preferred Stock
Shares
Preferred stock, shares outstanding		4,300			4,300			4,575
Preferred Stock | Series A Preferred Stock
Shares
Number of common shares issued for each convertible Series A preferred stock		(275,000)			(275,000)
Common Stock
Stockholders' Equity
Stock Issued During Period, Shares, New Issues			123,255
Shares
Number of common shares issued for each convertible Series A preferred stock		55,000,000			55,000,000
Stock option
Stockholders' Equity
Total compensation cost		$ 3,388		$ 2,760	$ 9,817	$ 10,650
Stock Options
Outstanding (in shares)		5,790,813			5,790,813
Outstanding, weighted-average exercise price (in dollars per share)		$ 10.99			$ 10.99
Granted (in shares)					1,878,607
Granted (in dollars per share)					$ 9.06
Stock option | Research and development.
Stockholders' Equity
Total compensation cost		$ 1,210		1,060	$ 3,615	3,333
Stock option | Selling, general and administrative
Stockholders' Equity
Total compensation cost		$ 2,178		1,700	$ 6,202	7,317
Restricted common stock
Stockholders' Equity
Vesting period					2 years
Shares
Outstanding (in shares)		12,500			12,500
Restricted Stock Units
Stockholders' Equity
Vesting period					4 years
Restricted stock awards and restricted stock units
Stockholders' Equity
Total compensation cost		$ 507		81	$ 1,274	217
Restricted stock awards and restricted stock units | Research and development.
Stockholders' Equity
Total compensation cost		184			454
Restricted stock awards and restricted stock units | Selling, general and administrative
Stockholders' Equity
Total compensation cost		$ 323		$ 81	$ 820	$ 217
2005 Plan
Stockholders' Equity
Common stock reserved for issuance (in shares)		0			0
2005 Plan | Stock option
Stock Options
Outstanding (in shares)		577			577
2014 Plan
Stockholders' Equity
Common stock reserved for issuance (in shares)		888,309			888,309		2,343,330
2014 Plan | Stock option
Stock Options
Outstanding (in shares)		3,833,770			3,833,770
Granted (in shares)					1,230,471
2014 Plan | Restricted Stock Units
Shares
Issued (in shares)					801,028
Outstanding (in shares)		710,732			710,732
Equity Incentive Plan, Employee Inducements | Stock option
Stock Options
Outstanding (in shares)		1,956,466			1,956,466
Granted (in shares)					648,136