Stockholders' Equity (Details) - USD ($) $ / shares in Units, $ in Thousands		3 Months Ended			6 Months Ended
	Mar. 29, 2022	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Jan. 01, 2022	Dec. 31, 2021
Stockholders' Equity
Total compensation cost		$ 3,351		$ 2,910	$ 6,429	$ 7,890
Shares
Number of common shares issued for each convertible Series A preferred stock		860,000			860,000
Ovid License Agreement
Stockholders' Equity
Stock Issued During Period, Shares, New Issues	123,255
Series A Preferred Stock
Shares
Preferred stock, shares outstanding		4,300			4,300			4,575
Preferred Stock | Series A Preferred Stock
Shares
Number of common shares issued for each convertible Series A preferred stock		(275,000)			(275,000)
Conversion of convertible preferred stock to common stock (in shares)		(275)		(178)
Common Stock
Stockholders' Equity
Stock Issued During Period, Shares, New Issues			123,255
Shares
Number of common shares issued for each convertible Series A preferred stock		55,000,000			55,000,000
Conversion of convertible preferred stock to common stock (in shares)		55,000		35,600
Stock option
Stock Options
Outstanding (in shares)		5,721,407			5,721,407
Outstanding, weighted-average exercise price (in dollars per share)		$ 11.32			$ 11.32
Granted (in shares)					1,608,519
Restricted stock awards and RSUs
Stockholders' Equity
Total compensation cost		$ 466		$ 81	$ 767	136
Stock Options
Outstanding (in shares)		15,125			15,125
Shares
Issued (in shares)					771,234
Outstanding (in shares)		743,092			743,092
Restricted stock awards and RSUs | Research and development.
Stockholders' Equity
Total compensation cost		$ 171			$ 270
Restricted stock awards and RSUs | General and administrative
Stockholders' Equity
Total compensation cost		$ 295		81	$ 497	136
2005 Plan
Stockholders' Equity
Common stock reserved for issuance (in shares)		0			0
2005 Plan | Stock option
Stock Options
Outstanding (in shares)		577			577
2014 Plan
Stockholders' Equity
Common stock reserved for issuance (in shares)		700,490			700,490		2,343,330
2014 Plan | Research and development.
Stockholders' Equity
Total compensation cost		$ 1,226		1,083	$ 2,405	2,273
2014 Plan | General and administrative
Stockholders' Equity
Total compensation cost		$ 2,125		$ 1,827	$ 4,024	$ 5,617
2014 Plan | Stock option
Stock Options
Outstanding (in shares)		2,791,555			2,791,555
Granted (in shares)					1,218,783
Equity Incentive Plan, Employee Inducements | Stock option
Stock Options
Outstanding (in shares)		2,929,275			2,929,275
Granted (in shares)					389,736