License and Collaboration Revenue - Allocation of the transaction price to the performance obligations (Details) $ in Thousands, € in Millions			12 Months Ended
	Jul. 30, 2021 USD ($) item	Jul. 30, 2021 EUR (€) item	Dec. 31, 2021 USD ($)	Dec. 31, 2021 EUR (€)
License and Collaboration Revenue
Net contract asset			$ 557
Cost of collaboration revenue			1,478
Collaboration Agreement with Orion
License and Collaboration Revenue
Number of performance obligations | item	3	3
Transaction Price			15,717
Cumulative Collaboration Recognized			9,093
Contract Liability			6,624
Less current portion of contract liability			(869)
Total long-term contract liability			5,755
Contract asset			7,200
Net contract asset			600
Incremental costs incurred in obtaining the agreement			2,000
Contract acquisition costs included in general and administrative expense			1,100
Capitalized contract costs			900
Cost of collaboration revenue			1,500
Upfront fee received	$ 29,600	€ 25.0		€ 25.0
Collaboration Agreement with Orion | License Revenue
License and Collaboration Revenue
Transaction Price			8,987
Cumulative Collaboration Recognized			8,987
Collaboration Agreement with Orion | Development and Regulatory Services
License and Collaboration Revenue
Transaction Price			2,787
Cumulative Collaboration Recognized			106
Contract Liability			2,681
Collaboration Agreement with Orion | Supply of License Product
License and Collaboration Revenue
Transaction Price			3,943
Contract Liability			$ 3,943