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Commitments and Contingencies (Details)
$ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2018
USD ($)
ft²
Nov. 30, 2018
ft²
item
Dec. 31, 2015
ft²
Dec. 31, 2018
USD ($)
ft²
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Leases            
Operating lease agreement term   3 years        
Rental square feet office space | ft²   1,000 4,000      
Number of operating lease annual renewal options | item   0        
Rent expense under operating lease       $ 200 $ 300 $ 300
Annual future minimum lease payments            
2019 $ 298     298    
2020 807     807    
2021 819     819    
2022 807     807    
2023 823     823    
Thereafter 1,482     1,482    
Total minimum lease payments $ 5,036     $ 5,036    
Employee Benefit Plan            
Maximum employees contribution (as a percent)       50.00%    
Vesting period       4 years    
Amended Lease            
Leases            
Operating lease agreement term     62 months      
Rental square feet office space | ft²     8,500      
Second Amended Lease            
Leases            
Operating lease agreement term 78 months          
Rental square feet office space | ft² 22,500     22,500    
License Agreement | Purdue Neuroscience Company            
License agreement            
Expiration period of obligation to pay royalties       10 years