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Stockholders' Equity (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Stock options    
Stock option and incentive plans    
Total compensation cost $ 1,091 $ 661
Stock Options    
Outstanding (in shares) 4,624,320  
Outstanding, weighted-average exercise price (in dollars per share) $ 5.47  
Granted (in shares) 870,000  
Granted (in dollars per share) $ 6.55  
Stock options | Research and development    
Stock option and incentive plans    
Total compensation cost $ 313 195
Stock options | General and administrative    
Stock option and incentive plans    
Total compensation cost 778 466
Restricted stock    
Stock option and incentive plans    
Total compensation cost $ 35 $ 86
Shares    
Outstanding (in shares) 125,867  
Issued (in shares) 0 245,200
Vested (in shares) 113,933  
Restricted stock | Minimum    
Stock option and incentive plans    
Vesting period 1 year  
Restricted stock | Maximum    
Stock option and incentive plans    
Vesting period 3 years  
Restricted stock | Research and development    
Stock option and incentive plans    
Total compensation cost $ 7 $ 18
Restricted stock | General and administrative    
Stock option and incentive plans    
Total compensation cost $ 28 $ 68
2005 Plan    
Stock option and incentive plans    
Common stock reserved for issuance (in shares) 0  
2005 Plan | Stock options    
Stock Options    
Outstanding (in shares) 364,420  
2014 Plan    
Stock option and incentive plans    
Common stock reserved for issuance (in shares) 1,317,100  
2014 Plan | Stock options    
Stock Options    
Outstanding (in shares) 4,259,900  
2014 Plan | Restricted stock    
Shares    
Outstanding (in shares) 125,567