<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: EVENTIDE ASSET MANAGEMENT, LLC -->
          <cik>0001442891</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>8</amendmentNo>
      <securitiesClassTitle>Common Stock, par value $0.001 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001267565</issuerCik>
        <issuerName>COLLEGIUM PHARMACEUTICAL, INC</issuerName>
        <issuerCusips>
          <issuerCusipNumber>19459J104</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>100 Technology Center Drive</com:street1>
          <com:city>Stoughton</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02072</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Eventide Asset Management, LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>1424282.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>1424282.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1424282.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.5</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Finny Kuruvilla, M.D. Ph. D.</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1424282.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1424282.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1424282.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.5</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Robin C. John</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1424282.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1424282.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1424282.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.5</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>COLLEGIUM PHARMACEUTICAL, INC</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>100 Technology Center Drive, Stoughton, MA 02072</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>(i)    Eventide Asset Management, LLC ("Eventide")
(ii)   Finny Kuruvilla, M.D., Ph.D. ("Kuruvilla")
(iii)  Robin C. John ("John")</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>Eventide, Kuruvilla and John:
One International Place, Suite 4210
Boston, Massachusetts 02110</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Eventide:  Delaware
Kuruvilla:  United States
John:  United States</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>(i)     Eventide: 1,424,282
(ii)    Kuruvilla: 1,424,282
(iii)   John:       1,424,282</amountBeneficiallyOwned>
        <classPercent>(i)     Eventide:     4.5%
(ii)    Kuruvilla:     4.5%
(iii)   John:           4.5%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>(1)   Eventide:     1,424,282
(2)   Kuruvilla:     0
(3)   John:           0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>(1)   Eventide: 0
(2)   Kuruvilla: 1,424,282
(3)   John: 1,424,282</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>(1)   Eventide:     1,424,282
(2)   Kuruvilla:     0
(3)   John:           0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>(1)   Eventide: 0
(2)   Kuruvilla: 1,424,282
(3)   John: 1,424,282</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

In accordance with Rule 13d-4 of the Securities Exchange Act of 1934, each of the persons filing this statement expressly disclaim the beneficial ownership of the securities covered by this statement and the filing of this report shall not be construed as an admission by such persons that they are the beneficial owners of such securities.</certifications>
      </item10>
    </items>
    <exhibitInfo>EXHIBIT 1 - Filed Herewith</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>Eventide Asset Management, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Peter J. Luiso</signature>
        <title>Peter J. Luiso, General Counsel</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Finny Kuruvilla, M.D. Ph. D.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Finny Kuruvilla, M.D., Ph. D.</signature>
        <title>Finny Kuruvilla, M.D., Ph. D.</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Robin C. John</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Robin C. John</signature>
        <title>Robin C. John</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
