CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017
Operating activities
Net loss	$ (31,712)	$ (44,199)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and other amortization expense	578	332
Nucynta amortization expense	61,933	177
Lease incentive obligation		(17)
Stock-based compensation expense	6,254	3,767
Non-cash interest expense	11,471
Changes in operating assets and liabilities:
Accounts receivable	(58,411)	(2,748)
Inventories	(508)	(204)
Prepaid expenses and other assets	(608)	(1,083)
Accounts payable	13,008	(3,494)
Accrued expenses	13,917	1,074
Accrued rebates, returns and discounts	69,346
Deferred revenue		5,417
Net cash provided by (used in) operating activities	85,268	(41,155)
Investing activities
Cash paid for asset acquisition	(18,877)
Purchases of property and equipment	(987)	(478)
Net cash used in investing activities	(19,864)	(478)
Financing activities
Cash paid for common stock offerings costs	(30)	(87)
Proceeds from issuances of common stock from employee stock purchase plans	510	673
Proceeds from term loan amendment, net of repayment of amended term loan	10,020
Repayment of asset acquisition obligations	(64,500)
Repayment of term note		(1,333)
Proceeds from the exercise of stock options	3,905	415
Payments made for employee restricted stock tax withholdings	(356)	(51)
Net cash used in financing activities	(50,451)	(383)
Net increase (decrease) in cash, cash equivalents and restricted cash	14,953	(42,016)
Cash, cash equivalents and restricted cash at beginning of period	118,794	153,322
Cash, and cash equivalents and restricted cash at end of period	133,747	111,306
Supplemental disclosure of cash flow information
Cash paid for offering costs	30	87
Cash paid for interest	242	88
Supplemental disclosure of non-cash activities
Offering costs in accrued expenses	25	25
Acquisition of property and equipment in accrued expenses	1,184	$ 304
Liabilities assumed from asset acquisition in accrued rebates, returns and discounts	$ 22,660