CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2018	Mar. 31, 2017
Revenues
Product revenues, net	$ 63,749	$ 2,172
Costs and expenses
Cost of product revenues	43,106	371
Research and development	2,268	2,130
Selling, general and administrative	31,582	22,847
Total costs and expenses	76,956	25,348
Loss from operations	(13,207)	(23,176)
Interest expense	(5,700)
Interest income	255	98
Net loss	$ (18,652)	$ (23,078)
Loss per share - basic and diluted	$ (0.57)	$ (0.79)
Weighted-average shares - basic and diluted	32,903,674	29,350,268

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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