CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues
Product revenues, net	$ 28,476	$ 1,711
Costs and expenses
Cost of product revenues	2,595	213
Research and development	8,572	14,948	$ 7,975
Selling, general and administrative	92,756	80,632	18,932
Total costs and expenses	103,923	95,793	26,907
Loss from operations	(75,447)	(94,082)	(26,907)
Other income (expense)
Interest income (expense), net	582	(94)	(439)
Gain on extinguishment of debt			91
Total other income (expense), net	582	(94)	(348)
Net loss	$ (74,865)	$ (94,176)	$ (27,255)
Loss per share - basic and diluted	$ (2.47)	$ (3.88)	$ (1.48)
Weighted-average shares - basic and diluted	30,265,262	24,262,945	13,542,282