CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2017	Mar. 31, 2016
Revenues
Product revenues, net	$ 2,172
Costs and expenses
Cost of product revenues	371
Research and development	2,130	$ 4,062
Selling, general and administrative	22,847	11,525
Total costs and expenses	25,348	15,587
Loss from operations	(23,176)	(15,587)
Other expense (income):
Interest income (expense), net	98	(66)
Total other income (expense), net	98	(66)
Net loss	$ (23,078)	$ (15,653)
Loss per share - basic and diluted	$ (0.79)	$ (0.68)
Weighted-average shares - basic and diluted	29,350,268	23,130,153

Total costs related to goods produced and sold during the reporting period.

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Amount after accretion (amortization) of discount (premium), and investment expense, of interest income and dividend income on nonoperating securities.

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The net result for the period of deducting operating expenses from operating revenues.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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