CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues
Product revenues, net	$ 1,711
Costs and expenses
Cost of product revenues	213
Research and development	14,948	$ 7,975	$ 14,959
Selling, general and administrative	80,632	18,932	2,706
Total costs and expenses	95,793	26,907	17,665
Loss from operations	(94,082)	(26,907)	(17,665)
Other expense (income):
Interest expense, net	94	439	252
Gain on extinguishment of debt		(91)
Change in fair value of derivative liability			7
Total other expense, net	94	348	252
Net loss	$ (94,176)	$ (27,255)	$ (17,917)
Loss per share - basic and diluted	$ (3.88)	$ (1.48)	$ (22.72)
Weighted-average shares - basic and diluted	24,262,945	13,542,282	933,997