X0508 4 2025-08-08 0001267565 COLLEGIUM PHARMACEUTICAL, INC COLL 0001296771 Freund John Gordon C/O COLLEGIUM PHARMACEUTICAL, INC. 100 TECHNOLOGY CENTER DRIVE STOUGHTON MA 02072 1 0 0 0 0 Common Stock 2025-08-08 4 S 0 11659 34.3632 D 23129 I By: John Freund Family Partnership IV, L.P. Common Stock 70658 D Common Stock 8625 I By: Skyline Venture Management V, LLC The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.27 to $34.535, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The shares are held by the John Freund Family Partnership IV, L.P. ("Freund LP"). The Reporting Person is the trustee and beneficiary of the The John G. Freund Revocable Trust u/a/d 6/26/01 which serves as the general partner of Freund LP. The Reporting Person disclaims beneficial ownership of the shares held by Freund LP except to the extent of his proportionate pecuniary interest therein. The shares are held by Skyline Venture Management V, LLC. John G. Freund and Yasunori Kaneko are managers of Skyline Venture Management V, LLC. These individuals share voting and investment power over the shares held by Skyline Venture Management V, LLC. The Reporting Person disclaims beneficial ownership of all the shares held by Skyline Venture Management V, LLC except to the extent of his proportionate pecuniary interest therein. Exhibit 24.1 - Power of Attorney /s/ Colleen Tupper as Attorney-in-Fact for John G. Freund, MD 2025-08-12