X0508 4 2024-11-12 0001267565 COLLEGIUM PHARMACEUTICAL, INC COLL 0001699488 Karnani Vikram C/O COLLEGIUM PHARMACEUTICAL, INC. 100 TECHNOLOGY CENTER DRIVE STOUGHTON MA 02072 1 1 0 0 President and CEO 0 Common Stock 2024-11-12 4 A 0 105972 0.00 A 105972 D Stock Option (Right to Purchase) 31.41 2024-11-12 4 A 0 130344 0.00 A 2034-11-12 Common Stock 130344 130344 D Reflects the grant of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock. Twenty-five percent (25%) of the RSUs shall vest on November 12, 2025, with the balance vesting in three annual installments thereafter, subject to the Reporting Person's continued service with the Issuer. The RSUs will be settled on each applicable vesting date in shares of the Issuer's common stock. Twenty-five percent (25%) of the option shall vest and become exercisable on November 12, 2025, with the balance vesting in equal quarterly installments thereafter, subject to the Reporting Person's continued service with the Issuer. /s/ Shirley R. Kuhlmann as Attorney-In-Fact For Vikram Karnani 2024-11-14