X0508 4 2024-09-05 0001267565 COLLEGIUM PHARMACEUTICAL, INC COLL 0001734919 Kuhlmann Shirley R. C/O COLLEGIUM PHARMACEUTICAL, INC. 100 TECHNOLOGY CENTER DRIVE STOUGHTON MA 02072 0 1 0 0 EVP and General Counsel 0 Common Stock 2024-09-05 4 S 0 16848 38.1800 D 122561 D Common Stock 2024-09-05 4 S 0 2400 39.1421 D 120161 D Common Stock 2024-09-06 4 S 0 977 37.4556 D 119184 D The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $38.00 to $38.92, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2) and (3) to this Form 4. The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $39.01 to $39.20, inclusive. The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $37.455 to $37.4592, inclusive. /s/ Shirley R. Kuhlmann 2024-09-06