X0508 4 2024-05-23 0001267565 COLLEGIUM PHARMACEUTICAL, INC COLL 0001746251 Dreyer Scott C/O COLLEGIUM PHARMACEUTICAL, INC. 100 TECHNOLOGY CENTER DRIVE STOUGHTON MA 02072 0 1 0 0 EVP & Chief Commercial Officer 0 Common Stock 2024-05-23 4 M 0 51209 24.03 A 190127 D Common Stock 2024-05-23 4 S 0 51209 33.8240 D 138918 D Common Stock 2024-05-24 4 M 0 23791 24.03 A 162709 D Common Stock 2024-05-24 4 S 0 56807 33.9827 D 105902 D Stock Option (Right to Purchase) 24.03 2024-05-23 4 M 0 51209 0 D 2028-04-04 Common Stock 51209 23791 D Stock Option (Right to Purchase) 24.03 2024-05-24 4 M 0 23791 0 D 2028-04-04 Common Stock 23791 0 D The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.36 to $34.19, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1) and (2) to this Form 4. The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.68 to $34.25, inclusive. The option is fully vested and exercisable. /s/ Shirley R. Kuhlmann as Attorney-In-Fact For Scott Dreyer 2024-05-28