<?xml version="1.0"?><ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-11-18</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000022872</issuerCik><issuerName>COMPREHENSIVE CARE CORP</issuerName>        <issuerTradingSymbol>CHCR</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001264656</rptOwnerCik><rptOwnerName>CLAY THOMAS C</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>200 SOUTH HOOVER BLVD.,</rptOwnerStreet1><rptOwnerStreet2>BLDG. 219, SUITE 200</rptOwnerStreet2><rptOwnerCity>TAMPA</rptOwnerCity><rptOwnerState>FL</rptOwnerState><rptOwnerZipCode>33609</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>0</isDirector><isOfficer>1</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle>Chief Development Officer</officerTitle></reportingOwnerRelationship></reportingOwner><nonDerivativeTable><nonDerivativeHolding><securityTitle><value>Common</value></securityTitle><postTransactionAmounts><sharesOwnedFollowingTransaction><value>5000.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeHolding></nonDerivativeTable><derivativeTable><derivativeTransaction><securityTitle><value>Option to purchase Common Stock</value></securityTitle><conversionOrExercisePrice><value>2.1600</value></conversionOrExercisePrice><transactionDate><value>2003-11-18</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>10000.0000</value></transactionShares><transactionPricePerShare><value>2.1600</value><footnoteId id="F2" /></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2004-05-18</value><footnoteId id="F1" /></exerciseDate><expirationDate><value>2013-11-18</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common</value></underlyingSecurityTitle><underlyingSecurityShares><value>10000.0000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>57500.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">Note 1 - options to purchase 5,000 shares vest on 5/18/04; options to purchase remaining 5,000 shares vest on 11/18/04.</footnote><footnote id="F2">Note 2 - These options were granted pursuant to the Company's 2002 Incentive Plan, an employee stock option plan, at a price equal to the market price on the date of grant, which is $2.16.</footnote></footnotes><remarks></remarks><ownerSignature><signatureName>/s/ Cathy J. Welch, as Attorney-in-fact for Thomas C. Clay</signatureName><signatureDate>2003-11-19</signatureDate></ownerSignature></ownershipDocument>

