0001104659-18-042159.txt : 20180626 0001104659-18-042159.hdr.sgml : 20180626 20180626083021 ACCESSION NUMBER: 0001104659-18-042159 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 4 CONFORMED PERIOD OF REPORT: 20180625 ITEM INFORMATION: Other Events ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20180626 DATE AS OF CHANGE: 20180626 FILER: COMPANY DATA: COMPANY CONFORMED NAME: STEMLINE THERAPEUTICS INC CENTRAL INDEX KEY: 0001264587 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 450522567 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 001-35619 FILM NUMBER: 18918321 BUSINESS ADDRESS: STREET 1: 750 LEXINGTON AVENUE STREET 2: ELEVENTH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: 646-502-2311 MAIL ADDRESS: STREET 1: 750 LEXINGTON AVENUE CITY: NEW YORK STATE: NY ZIP: 10022 8-K 1 a18-16033_18k.htm 8-K

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C.  20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

 

Date of report (Date of earliest event reported):  June 25, 2018

 

Stemline Therapeutics, Inc.

(Exact Name of Registrant as Specified in Charter)

 

Delaware
(State or Other Jurisdiction
of Incorporation)

 

001-35619
(Commission File Number)

 

45-0522567
(IRS Employer Identification
No.)

 

750 Lexington Avenue

Eleventh Floor

New York, New York 10022

(Address of Principal Executive Offices)

 

(646) 502-2311

(Registrant’s telephone number, including area code)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

o                                    Written communications pursuant to Rule 425 under the Securities Act.

o                                    Soliciting material pursuant to Rule 14a-12 under the Exchange Act.

o                                    Pre-commencement communications pursuant to Rule 14d-2b under the Exchange Act.

o                                    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

 

Emerging growth company x

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. x

 

 

 


 

Item 8.01 Other Events.

 

On June 25, 2018, Stemline Therapeutics, Inc. announced it completed the submission of its Biologics License Application (BLA) for ELZONRIS (tagraxofusp; SL-401), a targeted therapy directed to the interleukin-3 receptor (CD123), to the U.S. Food and Drug Administration (FDA).

 

A copy of the press release is being furnished as Exhibit 99.1 to this report.

 

Item 9.01. Financial Statements and Exhibits.

 

(d) Exhibits.

 

The following exhibit is furnished herewith:

 

Exhibit
Number

 

Description

 

 

 

99.1

 

Press release issued by Stemline Therapeutics, Inc., dated June 25, 2018.

 

2


 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

 

Stemline Therapeutics, Inc.

 

(Registrant)

 

 

 

 

 

By

/s/ Kenneth Hoberman

 

 

Kenneth Hoberman

 

 

Chief Operating Officer

 

 

 

 

Date: June 26, 2018

 

 

3

 EX-99.1 2 a18-16033_1ex99d1.htm EX-99.1

Exhibit 99.1

 

 

Stemline Therapeutics Announces Completion of Rolling BLA Submission for ELZONRIS™ (tagraxofusp; SL-401) for the Treatment of BPDCN

 

NEW YORK, June 25, 2018 (GLOBE NEWSWIRE) — Stemline Therapeutics, Inc. (Nasdaq: STML), a clinical-stage biopharmaceutical company developing novel oncology therapeutics, announced today that it has completed submission of a rolling Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ELZONRISTM (tagraxofusp; SL-401), a potential treatment for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a CD123+ malignancy of unmet medical need for which the agent was awarded Breakthrough Therapy Designation (BTD).

 

Ivan Bergstein, M.D., Stemline’s CEO, commented, “The completion of our rolling BLA submission is a major milestone for Stemline and the overall BPDCN patient community. We want to recognize the hard work of our dedicated investigators as well as the entire Stemline team in completing this submission. We also want to especially thank all of the patients and their families who participated in the clinical development program. We are committed to bringing this promising agent to BPDCN patients as rapidly as possible.”

 

BPDCN Efficacy — Stages 1, 2, and 3, ELZONRIS (12mg/kg/day) (n=42)

 

The trial of investigational agent, ELZONRIS, in patients with BPDCN was comprised of 3 stages, with Stage 3 serving as the pivotal cohort for confirmation of efficacy. To ensure ongoing access to ELZONRIS, patients with BPDCN are being enrolled in an additional cohort, Stage 4. Stage 3 met its primary endpoint with a CR+CRc (complete response + clinical complete response) rate of 54% (95% CI: 25.1, 80.8). A summary of efficacy results is shown below.

 

Summary table: Efficacy of ELZONRIS (12mg/kg/day) in patients with BPDCN (Stages 1, 2 and 3 [n=42])

 

Line of Therapy

 

First-line

 

Relapsed /
Refractory

n

 

29

 

13

ORR, n (%)

 

26 (90%)

 

9 (69%)

CR+CRc+CRi, n (%)

 

21 (72%)

 

5 (38%)

CR

 

12

 

1

CRc

 

7

 

3

CRi

 

2

 

1

PR, n (%)

 

5 (17%)

 

4 (31%)

Bridged to SCT, n (%)

 

13 (45%)

 

1 (8%)

 

Abbreviations: ORR=overall response rate; CR=complete response; CRc=clinical CR (CR with minimal residual skin abnormality); CRi=CR with incomplete hematologic recovery; PR=partial response; SCT=stem cell transplant.

 

Overall Safety

 

148 patients received ELZONRIS (12mg/kg/day) across all Stemline-sponsored trials, including in BPDCN, myeloproliferative neoplasms, and acute myeloid leukemia. A summary of safety results is shown below.

 


 

Summary table: Safety and tolerability of ELZONRIS (12mg/kg/day) in all Stemline-sponsored clinical trials (n=148)

 

Most Common Adverse Events (AEs) (>15% treatment-related AEs, TRAEs)

 

 

 

All Grades, n (%)

 

 

 

TRAEs, n (%)

 

 

Preferred Term

 

TRAEs

 

All AEs

 

Gr 1-2

 

Gr 3

 

Gr 4

 

Gr 5

ALT increased

 

65 (43.9%)

 

80 (54.1%)

 

31 (20.9%)

 

34 (23.0%)

 

0 (0.0%)

 

0 (0.0%)

AST increased

 

65 (43.9%)

 

74 (50.0%)

 

30 (20.3%)

 

31 (20.9%)

 

4 (2.7%)

 

0 (0.0%)

Hypoalbuminaemia

 

65 (43.9%)

 

73 (49.3%)

 

64 (43.2%)

 

1 (0.7%)

 

0 (0.0%)

 

0 (0.0%)

Thrombocytopenia

 

39 (26.4%)

 

48 (32.4%)

 

7 (4.7%)

 

8 (5.4%)

 

24 (16.2%)

 

0 (0.0%)

Nausea

 

38 (25.7%)

 

70 (47.3%)

 

37 (25.0%)

 

1 (0.7%)

 

0 (0.0%)

 

0 (0.0%)

Pyrexia

 

33 (22.3%)

 

60 (40.5%)

 

33 (22.3%)

 

0 (0.0%)

 

0 (0.0%)

 

0 (0.0%)

Fatigue

 

30 (20.3%)

 

67 (45.3%)

 

26 (17.6%)

 

4 (2.7%)

 

0 (0.0%)

 

0 (0.0%)

Weight increased

 

28 (18.9%)

 

42 (28.4%)

 

28 (18.9%)

 

0 (0.0%)

 

0 (0.0%)

 

0 (0.0%)

Chills

 

26 (17.6%)

 

40 (27.0%)

 

25 (16.9%)

 

1 (0.7%)

 

0 (0.0%)

 

0 (0.0%)

Capillary leak syndrome (CLS)(a)

 

25 (16.9%)

 

25 (16.9%)

 

16 (10.8%)

 

5 (3.4%)

 

3 (2.0%)

 

1 (0.7%)

Hypotension

 

23 (15.5%)

 

36 (24.3%)

 

17 (11.5%)

 

5 (3.4%)

 

1 (0.7%)

 

0 (0.0%)

Oedema peripheral

 

22 (14.9%)

 

57 (38.5%)

 

21 (14.2%)

 

1 (0.7%)

 

0 (0.0%)

 

0 (0.0%)

 

(a)0.7% (1/148) for all trials (12mg/kg/day) and 1.6% (3/182) for all trials (all doses) were grade 5. A myocardial infarction, grade 5, was also reported in a patient who experienced a grade 4 CLS.

 

Overall Survival (OS)

 

In first-line BPDCN patients who received ELZONRIS (12mg/kg/day) in Stages 1, 2 and 3, the median OS has not been reached. Median follow up was 13.8 months (range: 0.2-37.4+ months).

 

 

About ELZONRISTM (tagraxofusp; SL-401)

ELZONRISTM (tagraxofusp; SL-401) is a novel targeted investigational therapy directed to CD123, a cell surface receptor expressed on a range of malignancies. ELZONRIS has successfully completed a pivotal trial in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an indication for which it was granted Breakthrough Therapy Designation (BTD). A rolling Biologics License Application (BLA) submission has been completed. ELZONRIS is also being evaluated in clinical trials in additional indications including chronic myelomonocytic leukemia (CMML), myelofibrosis (MF), acute myeloid leukemia (AML), and myeloma.

 

About BPDCN

 

Please visit the BPDCN disease awareness website: www.bpdcninfo.com.

 


 

About Stemline Therapeutics

 

Stemline Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing novel oncology therapeutics. Stemline is developing three clinical stage product candidates, ELZONRISTM (tagraxofusp; SL-401), SL-801, and SL-701. ELZONRIS is a targeted therapy directed to the interleukin-3 receptor (CD123) present on a range of malignancies. ELZONRIS has completed a pivotal trial in blastic plasmacytoid dendritic cell neoplasm (BPDCN), for which it was granted breakthrough therapy designation (BTD). The pivotal trial met its primary endpoint, and a rolling Biologics License Application (BLA) submission has been completed. ELZONRIS is also being evaluated in clinical trials in additional indications including chronic myelomonocytic leukemia (CMML), myelofibrosis (MF), acute myeloid leukemia (AML), and myeloma. SL-801 is a novel oral small molecule reversible inhibitor of XPO1 that is currently in a Phase 1 trial of patients with advanced solid tumors; dose escalation is ongoing. SL-701, an immunotherapeutic, has completed a Phase 2 trial in patients with second-line glioblastoma; data and next steps for the program are being evaluated.

 

Forward-Looking Statements

 

Some of the statements included in this press release may be forward-looking statements that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. The factors that could cause our actual results to differ materially include: the success and timing of our BLA submission to the FDA; the success and timing of our clinical trials and preclinical studies for our product candidates, including site initiation, institutional review board approval, scientific review committee approval, patient accrual, safety, tolerability and efficacy data observed, and input from regulatory authorities including the risk that the FDA or other ex-U.S. national drug authority ultimately does not agree with our data, find our data supportive of approval, or approve any of our product candidates; our plans to develop and commercialize our product candidates; market acceptance of our products; reimbursement available for our products; our available cash and investments; our ability to obtain and maintain intellectual property protection for our product candidates; our ability to obtain and maintain intellectual property protection for our product candidates; our ability to manufacture; the performance of third-party manufacturers, clinical research organizations, clinical trial sponsors and clinical trial investigators; and other risk factors identified from time to time in our reports filed with the SEC. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not intend to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof.

 

Contact

 

Investor Relations

Stemline Therapeutics, Inc.

750 Lexington Avenue

Eleventh Floor

New York, NY 10022

Tel: 646-502-2307

Email: investorrelations@stemline.com

 

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