144 0001263805 XXXXXXXX LIVE 0001631574 Wave Life Sciences Ltd. 001-37627 7 STRAITS VIEW, #12-00 MARINA ONE EAST TOWER, SINGAPORE U0 018936 U0 01893 617-949-2900 Henry Family Trust Affiliate Common J.P. Morgan Securities LLC

390 Madison Avenue 6th Floor New York NY 10017

93445 1730601 167181784 12/08/2025 Nasdaq Common 12/08/2025 Transfer, acquired via Stock Option Exercise Christian O Henry Y 12/08/2025 87000 12/08/2025 Cash Common 08/12/2025 Transfer, acquired via RSU Vesting Christian O Henry Y 08/12/2025 6445 08/12/2025 N/A Y 12/08/2025 08/06/2025 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Henry Family Trust